蛭龙通络方治疗慢性阻塞性肺疾病急性加重期临床疗效观察

摘要

Objective To observe the clinical cure effect of Zhilong Tongluo Decoction on chronic obstructive pulmonary disease in acute exacerbation(AECOPD). [Method] Take prospective research method to randomly divide 70 cases of AECOPD into 2 groups, the control one(35 cases) take routine western medicine(WM) for treatment, the treatment group(35), added with Zhilong Tongluo Decoction on the basis of control one. After being treated for 14d, compare their PH value, PaO2, PaCO2, HCT, ESR, CRP and clinical effect and side effects before and after treatment. [Result] The comparison of both groups had no difference of statistical meaning on PH,PaO2,PaCO2,HCT,ESR,CRP; after treatment, the PH and PaO 2 markedly increased, PaCO2 obviously decreased(P<0.05), so did HCT,ESR,CRP(P<0.05,P<0.01); the treatment group was much better than control one on improvement, so was the effective rate. Both had no marked side effects. [Conclusion] Zhilong Tongluo Decoction controls inflammation and improves ventilation and blood flow with its Tongluo(stretch col aterals), having obvious effect on AECOPD.%[目的]观察蛭龙通络方治疗慢性阻塞性肺疾病急性加重期（AECOPD）的临床疗效。[方法]采取前瞻性的研究方法将诊断为AECOPD的70例患者按随机原则分为两组，对照组35例予常规西医综合治疗，治疗组35例在对照组的基础上加蛭龙通络方治疗。治疗14d后比较两组患者治疗前后血液PH值、动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）、红细胞压积（HCT）、血沉（ESR）、C反应蛋白（CRP）、临床疗效及不良反应。[结果]两组治疗前PH、PaO2、PaCO2、HCT、ESR、CRP比较差异无统计学意义（P＞0.05）；治疗后两组PaO2明显升高（P＜0.05，P＜0.01），PaCO2明显降低（P＜0.05），HCT、ESR、CRP明显降低（P＜0.05，P＜0.01），治疗组PH明显升高（P＜0.05），各项指标改善程度治疗组优于对照组（P＜0.05，P＜0.01）；治疗组有效率明显高于对照组（P＜0.05）；两组均未见明显不良反应。[结论]蛭龙通络方以“通络”方法抑制炎症，改善通气及血流，结合常规西医综合治疗方法，对治疗AECOPD效果显著。