吴良村治疗胃癌的用药规律研究

摘要

[目的]探讨吴良村教授治疗胃癌的用药规律。[方法]纳入2014年1月1日至2014年12月31日期间吴良村教授在浙江省中医院门诊诊治的胃癌患者116例，采集患者临床信息，建立临床方剂基础数据库，对处方药味、用药频数、药物性味、药物功效进行描述性分析，并对频次10以上的42种药物进行系统聚类分析。[结果]在116例病例中共用药159种，累计用药频次1816，其中用药频次最多者为甘草，其后依次为茯苓、山药、太子参；药物类别使用频次最高的是补虚药（补气药类最多），其次为清热药、消食药、理气药；药性使用频次最多的为平性，药味使用频次最多的为甘味。聚类分析将药物主要分为5大类，涉及方剂四君子汤、二陈汤，涉及药对稻芽与麦芽、鸡内金与猕猴桃根、蛇舌草与仙鹤草等。[结论]吴老治疗胃癌以补气为主，其主方与四君子汤相类，同时注重养阴清热，顾护胃津，并常常辅以消食理气药物通畅中焦，疏利气机。%Objective]To summarize herbal medicine application regulation of Professor Wu Liangcun in gastric cancer treatment. [Methods]Collect 116 gastric cancer patients from Chinese medicine clinic system during January 1,2014 to December 31, 2014 and establish clinical prescription underlying database. Apply descriptive analysis to drug cumulative frequency, drug-induced taste and nature and apply cluster analysis to 42 drugs using more than 10 times. [Results] In the 116 gastric cancer patients,159 kinds of herbs were used ,the cumulative frequency of herbal medicine was 1816.GanCao was the herb with highest usage frequency, and then was FuLing, ShanYao, TaiZishen;According to accumulated frequency, herbs with tonifying function were at the top position(herbs with tonifying qi function were most), and then was the herbs with function of herbs with the function of clearing excessive heat, herbs with function of herbs with the function of relieving dyspepsia, herbs with function of herbs with the function of regulating qi. In terms of herbs' nature and taste, herbs with sweet taste, plain nature were used most. Cluster analysis divided all used herbs into 5 sections, involving prescriptions Sijunzi decoction, Erchen decoction, and couplet medicines DaoYa with GuYa, JiNeijin with MiHoutao, SheShecao with XianHecao and so on. [Conclusions] Professor Wu Liangcun treats gastric cancer with the law of tonifying qi, the main prescription is the same as Sijunzi decoction, emphasizing nourishing Yin and clearing away the heat-evil, protecting gastric, accompanied with promoting digestion and regulating qi.