三七总甙对小鼠坐骨神经功能恢复的影响

摘要

Obj ective:To study the effect of Panax Notoqino Sid PNS on the restoration of sciatic nerve inj ury and provide the basis for the repair and recovery of nerve inj ury.Methods:The sciatic nerve inj ury in mice to establish animal models,will be 40 mice were randomly divided into Panax notoqino sid PNS in-j ection the experimental group and inj ected with normal saline control group,one of the group was divided into drug plus exercise group and drug group did not exercise.After 30 days,through changes in body weight in mice,the sciatic nerve function index assessment and motor neuron counting function to observe the exercise and recovery in each group were compared.Results:Panax notoqino sid PNS inj ection group at weight gain,functional indices and the number of motor neurons on inj ection was superior to saline group,one of group exercise than non-exercise group.Conclusion:Inj ection Panax notoqino sid PNS on the sciatic nerve inj ury repair and restoration of sports have better results.%目的：：研究三七总甙对坐骨神经损伤小鼠神经形态和功能恢复的影响,为坐骨神经损伤后的恢复提供康复依据。方法：以切断 SD小鼠的坐骨神经建立周围神经损伤运动模型,将40只SD小鼠随机分成实验组和对照组,其中各组又分为药物加运动组和注射药物不运动组,然后隔天在伤口近端进行药物注射和每天进行一次跑台训练,连续4周,术后30 d,通过小鼠体重的变化、坐骨神经功能指数评定及运动神经元计数观察其运动功能恢复的情况并对各组进行比较。结果：在坐骨神经损伤侧近端注射药物加运动组和注射药物加不运动组与对照组相比较,从各项指标显示出其对损伤侧的坐骨神经损伤的恢复及运动恢复有明显的效果,药物组在体重增长、坐骨神经功能指数及运动神经元数目上明显优于生理盐水组,其中运动组又比不运动组好。结论：三七总甙对小鼠坐骨神经损伤后的恢复作用显著,运动恢复效果更佳。