卤代苯取代菊糖衍生物的合成及抑真菌活性研究

摘要

Using chemical modification,we graft antifungal groups (halogeno benzene and pyridine) onto inulin. The structure of target products is identified by infrared spectrometry and 1H-NMR. Their antifungal activities a-gainst three kinds of phytopathogens are estimated in vitro,respectively. The inhibitory property of all the obtained inulin derivatives exhibites a remarkable improvement over raw material. Of all the synthesized inulin derivatives, compound 4ClPhPyAIL reveals the strongest antifungal ability with inhibitory indices of 61%,49%, and 46% a-gainst Colletotrichum lagenarium(Pass) Ell.et halst,Fusarium oxysporum(schl.) F.sp. niveum(F. oxysporum) and Phomopsis asparagi(Sacc.) Bubak at 1.0 mg/mL,respectively. These data demonstrate that chemical modifi-cation is a powerful way to improve biological activity of inulin. Furthermore, these experiments have provided a new idea for expioit of high-value inulin products.%通过化学修饰的方法,将卤代苯及吡啶接入菊糖.通过红外光谱法以及核磁共振氢谱法对目标化合物进行了结构鉴定,并在体外测试了其对三种植物病原体的抑真菌活性.结果表明,与菊糖相比,菊糖衍生物的抑菌活性明显提高,在浓度为1.0 mg/mL时,化合物4ClPhPyAIL对黄瓜炭疽病菌(Colletotrichum lagenarium)、西瓜枯萎病菌(Fusarium oxys-porium)和芦笋茎枯病菌(Phomopsis asparagi)的抑制率分别为61%、49%、46%.这些数据表明化学修饰是提高菊糖生物活性的有效方法,同时为菊糖的高值化产品的开发提供了新的思路.