18例胃肝样腺癌患者临床病理特点及预后分析

摘要

Objective To investigate the clinical,pathological features and prognostic factors of hepatoid adenocar-cinoma of the stomach(HAS),so as to improve the diagnosis and treatment of HAS.Methods A total of 18 HAS pa-tients who were admitted into the First People's Hospital of Guangyuan and Guangyuan Central Hospital in the past twenty years were enrolled.Their clinical features, risk factors and prognosis were analyzed.Results All patients presented lymphatic metastasis,where five patients showed liver metastasis before surgery.Pathologic staging,radical surgery and adjuvant chemotherapy were the risk factors for HAS patients(P<0.05).In the current study,the 3-year overall sur-vival rate was 9.9%,while the 3-year disease-free survival rate was 7.1%.Conclusions HAS is a highly malignant tumor,which is often easily misdiagnosed with very poor prognosis.Early diagnosis and early multidisciplinary treatment are essential to treat HAS.%目的 研究胃肝样腺癌的临床病理特点及预后因素,以改善其诊断及治疗.方法 回顾性研究广元市第一人民医院和广元市中心医院近20年来收治的18例胃肝样腺癌的临床病理资料,研究分析其临床特点、危险因素及预后.结果 18例病例均出现淋巴结转移,5例术前发生肝脏转移.病理分期、是否接受根治性手术治疗、是否接受辅助化疗为影响患者预后的相关危险因素(P<0.05).本组病例3年累积无病生存率为7.1%,3年累积总生存率为9.9%.结论 胃肝样腺癌是具有高度恶性的一类特殊胃癌,在临床及病理诊断中极易误诊,其预后较差,早期诊断、早期多学科治疗是改善该类疾病的关键.