Objective To investigate the curative effect of mechanical ventilation for treatment of neonatal pneumonia and the influences of mechanical ventilation on inflammatory factor.Methods A total of 84 neonatal pneumonia patients were selected and divided into two groups.The patients in control group (n =41) were treated with conventional therapy,based on this,the patients in breathing machine group were given mechanical ventilation by breathing machine.The effective rates and average stay,the changes of C-reactive protein(CRP),tumor necrosis factor-α (TNF-α),interleukin(IL)-6 and IL-10 before treatment and on the 10th day after treatment and the change of arterial oxygen before treatment and 24 hours after treatment were compared between the two groups.Results The effective rate in breathing machine group was significantly higher than that in control group,the average stay was shorter than that in control group(P ＜ 0.05).The arterial partial pressure of oxygen before treatment between the two groups had not significant difference(P ＞0.05).The arterial partial pressure of oxygen after treatment was significantly higher than before treatment in breathing machine group(P ＜ 0.05) ;while the arterial partial pressure of oxygen before and after treatment in control group had not significant difference(P ＞ 0.05).The arterial partial pressure of oxygen after treatment in breathing machine group was significantly higher than that in control group(P ＜ 0.05).The inflammatory index of patients between the two groups before treatment had no significant difference(P ＞ 0.05).The levels of CRP,TNF-α and IL-6 in breathing machine group after treatment were significantly lower than those before treatment,the level of IL-10 was significantly higher than that before treatment (P ＜ 0.05).After treatment,the levels of CRP,TNF-α and IL-6 in breathing machine group were significantly lower than those in control group,the level of IL-10 was significantly higher than that in control group(P ＜ 0.05).Conclusion Mechanical ventilation in the treatment of neonatal pneumonia can rapidly improve the supply of oxygen of patients and improve the treatment effective rates.%目的 探讨呼吸机治疗新生儿肺炎的疗效及其对炎性因子的影响.方法 选择84例新生儿肺炎患者分为2组,对照组41例给予常规治疗,呼吸机组43例在常规治疗的基础上采用呼吸机治疗.比较2组患者治疗有效率,治疗前及治疗第10天时血清C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、IL-10变化,治疗前及治疗24 h后动脉血氧变化.结果 呼吸机组治疗有效率高于对照组,平均住院时间短于对照组,差异均有统计学意义(P＜0.05).2组治疗前动脉血氧分压比较差异无统计学意义(P＞0.05).呼吸机组患儿治疗后动脉血氧分压高于治疗前,差异有统计学意义(P＜0.05);对照组治疗前后比较差异无统计学意义(P＞0.05).治疗后呼吸机组动脉血氧分压高于对照组,差异有统计学意义(P＜0.05).2组患儿治疗前各炎性指标比较差异无统计学意义(P＞0.05).呼吸机组和对照组患儿治疗后CRP、TNF-α及IL-6水平较治疗前下降,IL-10水平较治疗前升高,差异均有统计学意义(P＜0.05).治疗后呼吸机组患儿CRP、TNF-α及IL-6水平低于对照组,IL-10水平高于对照组,差异均有统计学意义(P＜0.05).结论 在新生儿肺炎治疗中,采用机械通气尽早改善患儿的氧供可提高治疗有效率.
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