MMP22蛋白在喉癌中表达的 Meta 分析

摘要

Objective To evaluate the expression and significance of MMP22 in Laryngeal Carcinoma . Methods With comprehensive retrieval of related literature that had been published in Medeline ,Embase and in China from academic journals collected in CBMdisc and other document database ,there were 7 arti-cles about case-control study which were selected into system to be evaluated .Meta-analysis software Rev-Man5 .1 was used to analyze the raw data and to calculate the value of combined odd ratio (OR) and 95%confidence interval (CI) .Results Meta-analyses showed that MMP22 in laryngeal carcinoma was higher than that of normal laryngeal tissue [OR =24 .30 ,(95% CI :13 .14 ~ 44 .92) ,P <0 .01];M M P22 in mod-erately differentiated laryngeal carcinoma and poorly differentiated laryngeal carcinoma was higher than that of well differentiated laryngeal carcinoma [OR =0 .24 ,(95% CI :0 .13 ~ 0 .43) ,P<0 .01];MMP22 in laryngeal carcinoma with lymph node metastasis was higher than that of without lymph node metastasis [OR =0 .31 ,(95% CI :0 .16 ~ 0 .57) ,P<0 .01] .Conclusion The high expression of MMP22 may play an important role in progression and prognosis of laryngeal carcinoma .%目的探讨基质金属蛋白酶22蛋白（MMP22）在喉癌中的表达及临床意义。方法选用Medline、Embase、中国学术期刊网全文数据库、万方数据库和维普数据库等数据库，全面检索国内外已发表的相关文献，最终进入系统评价的病例对照研究文献有7篇。应用Meta分析软件对各研究原始数据进行统计学处理，计算合并OR及95％CI。结果Meta分析显示，与喉正常组织相比，MMP22蛋白在喉癌中呈高表达[OR＝24．30，（95％CI：13．14～44．92），P＜0．01]；与高分化喉癌中MMP22蛋白对比，中、低分化的喉癌中MMP22蛋白呈高表达[OR＝0．24，（95％CI：0．13～0．43），P＜0．01]；与无淋巴结转移的喉癌相比，伴淋巴结转移的喉癌中MMP22蛋白呈高表达高表达[OR＝0．31，（95％CI：0．16～0．57），P＜0．01]。结论MMP22蛋白高表达可能在喉癌的发生、发展及预后中起重要作用。