Objective To explore the relationship between different Uyghur dialectical type and chemoradiotherapeutic effects of patients with advanced esophageal cancer(EC).Methods 300 patients with ⅢB-Ⅳ staging EC was enrolled and subtyped by Uyghur medicine theory before and after therapy.During six months′ follow-up,they would be re-evaluated by Uyghur medicine subtyping theory while observing their symptom,CT scan and so on.Results 284 patients were enrolled and received chemoradiotherapy.The Abnormal Savda was the major subtype of patients both before(81.05％,72.92％and 78.49％in Han,Uyghur and Kazak patients respectively)and after(90.53％,86.46％and 91.40％respectively)therapy without significant difference among the ethnic groups(χ+2=1.895,P>0.05;χ+2=1.399,P>0.05).However,there was significant difference of chemoradiotherapeutic effect between Abnormal Savda and non-Abnormal Savda(χ+2=2.286,P<0.05).The progressing rate was 51.82％VS 39.06％and effective rate 6.82％VS 17.19％.The Abnormal Savda increased after therapy(χ+2=15.209,P<0.05).Conclusion The Abnormal Savda was found to be the major subtype of patients with advanced esophageal cancer.The re-evaluation of EC by Uyghur dialectical subtyping could become an alternative method to estimate the short-term effects of patients after chemoradiotherapy.%目的 探讨维医分型与晚期食管癌放化疗疗效的关系.方法 选择300例ⅢB～Ⅳ期食管癌患者,按照维医分型标准对其放化疗前、后进行分型,并进行6个月及以上时间随访,通过观察临床症状及CT等检查结果评价其疗效(评价指标包括有效、稳定和进展),通过再次维医分型观察患者的体液类型变化.结果 284例患者完成6个月及以上时间随访,治疗前、后的维医分型均以异常黑胆质型为主,汉族、维吾尔族及哈萨克族患者治疗前、后异常黑胆质型所占比例分别为81.05％、72.92％、78.49％(χ+2=1.895,P>0.05,治疗前)和90.53％、86.46％、91.40％(χ+2=1.399,P>0.05,治疗后);异常黑胆质型与非异常黑胆质型患者的放化疗疗效存在差异(χ+2=2.286,P<0.05),其中前者有效率偏低(6.82％vs 17.19％)、进展率偏高(51.82％vs 39.06％);治疗前、后患者的维医分型发生变化,差异有统计学意义(χ+2=15.209,P<0.05).结论 异常黑胆质型为晚期食管癌患者的主要体液类型,维医分型可作为晚期食管癌放化疗疗效的评价方法之一.
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