目的评价肝动脉热灌注化疗联合TACE治疗结直肠癌肝转移的临床效果和安全性。方法70例结直肠癌肝转移患者随机分为治疗组(n=35)和对照组(n=35),治疗组采取肝动脉热灌注化疗联合TACE,对照组常温动脉化疗联合TACE,两次治疗间隔1月,3个周期后评价临床疗效、生活质量和不良反应。结果治疗组和对照组有效率分别为65.7%(23/35)和40.0%(14/35),差异有统计学意义(x2=5.64,P<0.05),治疗组的生活质量也明显改善(x2=5.41,P<0.05)。不良反应比较两组差异无统计学意义。结论肝动脉热灌注化疗联合TACE治疗结直肠癌肝转移具有较好的临床效果,可以提高患者生活质量。%Objective To evaluate the clinical effect and safety of transcatheter hepatic arterial thermo_chemotherapy combined with transcatheter arterial chemoembolization ( TACE ) for the treatment of hepatic metastases from colorectal carcinoma. Methods Totally 70 cases of hepatic metastases from colorectal carci_noma were randomly divided into treatment group(n=35) and control group(n=35). The patients in treat_ment group were treated with transcatheter hepatic arterial thermochemotherapy combined with TACE,while the patients in the control group with conventional( normal temperature) transcatheter hepatic arterial chemo_therapy combined with TACE. The treatment was repeated every month. The clinical effect, tosicity and quality of life were analyzed after three months. Results Treatment effect is 65. 7% (23/35) in treatment group and 40. 0%(14/35) in control group,the difference between two groups was statistically significant(x2=5. 64,P<0. 05). The quality of life was improved in treatment group than that of control group(x2=5. 41, P<0. 05). The side effects were found in two groups without significant difference. Conclusion Transcatheter hepatic arterial thermochemotherapy combined with TACE for the treatment of hepatic metastases from color_ectal carcinoma can increase the clinical effect and improve the quality of life.
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