1-(4'-乙炔基苯基)-4-正丙基2,6,7-三氧杂双环2.2.2辛烷的合成

摘要

以正戊醛为原料经Cannizzaro反应,脱水,酯化,合环和引入炔基5步反应,总收率为5%,成功合成了1-(4'-乙炔基苯基)-4-正丙基-2,6,7-三氧杂双环[2.2.2]辛烷.目标化合物的熔点及1H NMR谱,MS与文献报道一致.%1-( 4′-ethynylphenyl)-4-n-propyl-2, 6, 7-trioxabicyclo [ 2. 2. 2] octane (EBOB) was successfully synthesized from n-valeraldehyde as a starting material via Cannizzaro reaction, dehydration, esteration,cyclization and introducing the ethynyl group. The overall yield of it in five steps from n-valeraldehyde was 5 ％. The melting point, 1H NMR and MS spectra are consistent with the literature values.