带有远端双键的取代碘苯的合成

摘要

The derivatives of 1-butyl-3-enyl-2-iodo-benzene are very important in organic synthesis,but they are rarely reported in literatures because they are expensive or not commercialized. Hereby,we proposed a facile and general synthetic method for the iodobenzenes with a remote double bond (derivatives of 1-butyl-3-enyl-2-iodo-benzene). By using allylbromide maganesium reagent as the starting materials,coupling to 2-iodobenzyl bromides or addition to 2-iodobenzaldehyde,a series of iodobenzenes with a remote double bond were synthesized. The final products can be easily synthesized with high yield and without further purification. This method could be applied to the scaled-up synthesis,showing its practical value to prepare the target molecules.%由于1-（3-烯-丁基）-2-碘苯类衍生物在有机合成中具有重要的应用价值，但此类化合物的价格昂贵，或者没有被商业化，且其合成方法鲜见文献报道。报道了一种通用的制备带有远端双键的取代碘苯[1-（3-烯-丁基）-2-碘苯类衍生物]的合成方法：用烯丙基溴格氏试剂对溴苄进行交叉偶联，或者对芳香醛进行加成，所得的产物产率高，易分离，生成的1-（3-烯-丁基）-2-碘苯类化合物也可以进一步被修饰。本方法简单，方便快捷，也可以用于这些目标化合物的大量制备中，为这类远端双键取代碘苯化合物的合成提供一条重要的参考途径。