17-Iodo:benzoyloxy-9-chloro-D-homo-4-pregnene-3,20-di:one derivs. - prepd. by reacting 9-unsubstituted cpds. with iodo-benzene di:chloride under UV light, used esp. as pharmaceutical intermediates

摘要

New D-homo-4-pregnene-3,20-dione derivs. are cpds. of formula (I): where C1---C2 is a C-C single or double bond, R1 is H, OH or lower acyloxy, and R2 is H,F or CF3. (I) have pharmacological, e.g. antiinflammatory activity, but they are primarily useful as intermediates for other pharmacologically active substances, particularly 11-hydroxylated cpds.