含氟苯并噻唑基双酰胺衍生物合成及生物活性

摘要

Ten novel anthranilic diamides compounds containing fluorine and benzothiazole compounds were sythesized after benzo-ic acid containing fluorine unite chloridized by thionyl then coupled with 2-aminobenzoic acid,and cyclized in the existence of acetic anhydride ,then coupled with substituted benzo[d]thiazol-2-amine. Their structures were characterized by 1HNMR,13C NMR,IR and elemental analyses. The results of bioassay showed that in the concentration of 500 mg/L,the inhibition rates of compound IY2 and IV10 a-gainst tobacco mosaic virus (TMV) were 44.5% and 45.1% ,respectively.%含氟苯甲酸经酰氯化后与邻氨基苯甲酸反应,在醋酸酐中闭环后与取代苯并噻唑胺反应,合成10个含氟基苯并噻唑基邻甲酰氨基苯甲酰胺类化合物.其结构经核磁碳谱、氢谱、红外及元素分析确证.生物活性测试结果表明:当目标化合物质量浓度在500 mg/L时,Ⅳ2和Ⅳ10对烟草花叶病毒(TMV)的抑制率分别为44.5％和45.1％.