肝纤四项指标与B 型超声联合检测对晚期血吸虫病肝纤维化诊断的价值

摘要

Objective To explore the diagnostic value of the detection of hyaluronic acid (HA), layer mucin (LN), Type Ⅲserum collagen (PC Ⅲ) , and type Ⅳ collagen (CⅣ) combined with type-B ultrasonic examination in the diagnosis of liver fibrosis of advanced schistosomiasis. Methods The serum concentration of HA, LN, PC Ⅲ and C Ⅳ of 305 advanced schistosomiasis patients were detected by chemiluminescence im-munoassay (CLIA) method, and examined by type-B ultrasonic at the same time. Results With the development of liver fibrosis, the serum concentration of HA, LN, PC Ⅲ and CⅣ increased gradually. Conclusion It has diagnostic value to detect HA, LN, PCⅢ and CⅣ combined with type-B ultrasonic examination in the diagnosis of liver fibrosis of advanced schistosomiasis patients.%目的 探讨透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(CⅣ)与B 型超声检查对晚期日本血吸虫病(以下简称晚血)肝纤维化的诊断价值.方法 采用化学发光免疫分析法(CLIA)对305例晚血患者同时进行血清HA、LN、PCⅢ、CⅣ的浓度检测与B 型超声检查肝实质性纤维化程度.结果 随着晚血肝纤维化程度的发展,血清HA、LN、PCⅢ、CⅣ四项指标水平逐渐升高.结论 血清HA、LN、PCⅢ、CⅣ与超声联合检测在晚血肝纤维化诊断中具有一定的诊断价值.