北京地区输入性疟疾血细胞及生化检验指标变化的敏感性分析

摘要

Objective To investigate the clinical significance by determining the biochemical indicators on urine and blood for early diagnosis of imported malarial patients. Methods The parameters of urine and blood biochemistry were retrospectively analyzed in 55 clinically confirmed patients with imported malaria in Beijing area with multiple Logistic regression by using software SPSS 18.0, and the results were compared with health controls. Results The biochemical parameters, including decreased blood platelet(OR=0.980, P=0.003), elevated glutamic-oxaloacetic transaminase(OR=0.969, P=0.013) and blood urea nitrogen(OR=1.907, P=0.013), were statistically significant in early stage of infection in imported malarial patients. Conclusion Bio⁃chemical parameters changed significantly in the early stage of infection in patients of imported malaria, suggest⁃ing that determination of these indicators can lead to early diagnosis and treatment of this disease.%目的：分析输入性疟疾患者确诊前的各项血、尿常规和血生化等检查指标，探讨各检测参数指标的临床早期诊断方面的意义。方法使用SPSS 18.0软件，回顾性分析55例临床确诊输入性疟疾患者的各项血、尿常规和血生化等检查指标,并建立正常对照组。采用Logistic多元回归分析,初步完成输入性疟疾各检验参数指标的分析。结果血常规中血小板减少（OR=0.980，P=0.003），肝功能中谷草转氨酶升高（OR=0.969，P=0.013），和尿素氮的变化（OR=1.907，P=0.013），在疟疾早期各生化指标变化中具有明显意义。结论通过本次研究，初步表明血常规中血小板减少，肝功能中谷草转氨酶升高，和尿素氮的变化，在疟疾早期各生化指标变化中具有明显意义。其综合判断，有利于输入性疟疾诊断早期预警，降低误诊率，提高诊断率。对疟疾的临床早期诊断具有重要意义。