单核细胞/淋巴细胞比值在胃癌患者病程监测中的意义

摘要

Objective To assess the clinical significance of determining the monocyte to lymphocyte ra⁃tio (MLR) in evaluating the progress of gastric cancer. Methods The clinical data were reviewed in 51 cases of gastric cancer treated in our department between January 2007 and January 2013. Peripheral venous blood MLR was calculated in patients before and after initial treatment, periods in disease remission and progress, and the relationship between MLR variation and disease progress were statistically analyzed and compared with the healthy controls. Results Gastric cancer patients had higher MLR over the healthy control, and lower MLR after surgery, yet higher ratio in disease development after surgery. The difference was significant( P<0.01). Con⁃clusion MLR is an important indicator in monitoring the disease progress in patients of gastric cancer progres⁃sion monitoring.%目的：探讨单核细胞/淋巴细胞比值（monocyte-to-lymphocyte ratio, MLR）在胃癌患者病程监测中的临床价值。方法回顾性分析2007年1月至2013年1月期间我院肿瘤科收治的51例胃癌患者的临床资料，计算患者首次治疗前后、病情缓解前后和病情进展前后外周静脉血MLR，统计学分析MLR的变化与胃癌患者病情演变的关系；并设健康对照组。结果胃癌患者MLR水平显著高于健康对照组，术后患者MLR较术前水平下降，病情进展（PD）时MLR水平较术后明显增高，上述各组资料差异均有统计学意义（P<0.01）。结论 MLR在胃癌患者病程监测中具有重要意义。