革兰阳性细菌AIP型群体感应抑制剂的研究进展

摘要

Quorum sensing (QS) is a responding phenomenon of communication between bacteria,providing a new way to study treatment of bacterial infections.The QS system with autoinducter peptides (AIPs) as signaling molecules exist in a variety of gram-positive bacteria,and is considered as an important breakthrough in development of new drugs against gram-positive bacteria,such as Staphylococcus aureus.The AIP-based quorum sensing inhibitors (QSIs) discovered so far include two types of molecule,small and macro.The recent researches in these two types of molecule in AIP based QSIs were reviewed to provide a reference for developing of new antibacterial drugs.%以自诱导肽(autoinducter peptide) AIP为信号分子的细菌群体感应(quorum sensing,Qs)系统存在于多种革兰阳性细菌中,是研究新型抗金黄色葡萄球菌等革兰阳性细菌药物的重要突破口.目前发现的AIP型群体感应抑制剂(quorum sensing inhibitors,QSIs)有小分子与大分子2种类型,笔者对这2类AIP型QSIs的研究进展进行综述,为新型抗菌药物的研发提供理论依据.