不同铁螯合剂治疗输血依赖性铁过载的对比研究

摘要

目的：对比不同铁螯合剂对贫血患者长期输血治疗后铁过载的驱铁作用及安全性。方法：将24例反复输血的患者在血清铁蛋白（SF）水平相同条件下随机均分为三组，采用不同铁螯合剂去铁治疗，分别检测其在治疗后1个月、2个月、3个月的铁蛋白（SF）水平，并观察其治疗相关不良反应。结果：地拉罗司组在治疗后SF下降最明显，且不良反应最少。结论：地拉罗司治疗输血依赖性铁过载的效果最好，安全性较高，不良反应最少。%AIM:To compare the effects and safety of iron over-load of patients with anemia who received different iron chelators treatment after long-term transfusion.METHODS:Dividing the 24 patients who transfused blood repeatedly into three groups un-der the same condition of serum ferritin (SF)level for iron remov-al treatment with different iron chelators.Then we detected the se-rum ferritin (SF)level after treatment of 1 month,2 months and 3 months respectively,and observed the adverse reactions relative-ly.RESULTS:The group with Deferasirox that the SF level de-creased at most and had minimal adverse reactions after treat-ment.CONCLUSION:The best therapeutic efficacy for iron o-verload of transfusion dependency is Deferasirox which has high safety and minimal adverse reactions.