真菌抗原检测在侵袭性真菌病的早期诊断、指导治疗中发挥重要作用．真菌抗原检测包括1，3⁃β⁃D⁃葡聚糖检测、半乳甘露聚糖检测、隐球菌荚膜多糖抗原检测等，其中运用最广泛的是1，3⁃β⁃D⁃葡聚糖检测和半乳甘露聚糖检测．1，3⁃β⁃D⁃葡聚糖检测和半乳甘露聚糖检测受到很多因素影响，在具有不同影响因素的患者中其结果的判读不同．关于不同疾病患者的1，3⁃β⁃D⁃葡聚糖检测和半乳甘露聚糖检测诊断价值的临床研究甚多，但是系统阐述这两种检测方法影响因素的文献很少．本研究就影响这两种检测方法结果的众多因素进行综述，明确在不同影响因素下的临床意义，并正确指导诊疗．%Detection of antigens, especially galactomannan, 1, 3⁃β⁃D⁃glucan, plays an important role in the detection and treat⁃ment of fungal pathogens effectively and timely. There are lots of factors have influence on the test of galactomannan and 1, 3⁃β⁃D⁃glucan to a certain extent, which is important for interpretation of the results of those tests. Since amount of clinical trials focuse on those factors, few elucidate them systematically. The study will review such factors in this article aiming at guiding clinical diag⁃nosis and treatment.
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