Hydrogel microspheres were prepared with the dripping method,and the effect of parameters on the size, weight,drug loading,encapsulation efficiency and the vitro drug release properties of the microspheres were investigated. It has been found that the formulations were spherical with the average diameter of 1.34-1.59,mm,and the average mass was 1.74-3.45,mg. When the mass ratio of lecithin to pectin was 5∶4,the mass ratio of curcumin to pectin 16∶20,the mass concentration of ZnCl2,70,g/L,the mass concentration of pectin 40,g/L,and the mass concentration of NaOH 30,g/L,the encapsulation efficiency was 85.81%,drug loading 18.03%,and drug release in simulated intestines fluid for 8,h was only 1.64%;and then drug release in simulated colonic fluid for 36,h was 68.72%. The addition of lecithin has improved the per-formance of zinc-pectin-lecithin composite microspheres carrying curcumin.%采用滴制法制备载带姜黄素的卵磷脂/果胶锌凝胶球，以粒径、粒质量、载药量、包封率以及体外释药性能为评价指标，讨论工艺参数对评价指标的影响．实验制备的载带姜黄素的卵磷脂/果胶锌凝胶球成球均匀，平均粒径1.34～1.59,mm，平均粒质量1.74～3.45,mg．当卵磷脂与果胶的质量比为5∶4、药胶质量比为16∶20、氯化锌质量浓度为70,g/L、果胶质量浓度40,g/L、NaOH 质量浓度为30,g/L 时，载药量为18.03%，包封率为85.81%，模拟小肠液中8,h累积释药率为1.64%，再进入模拟结肠环境36,h 累积释药率为68.72%．结果表明，卵磷脂的加入改善了果胶锌凝胶球对姜黄素的载带效果以及缓释效果．
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