阻塞性呼吸睡眠暂停综合征与中枢呼吸驱动

摘要

目的：阐明不同浓度的CO2刺激对阻塞性呼吸睡眠暂停综合征的中枢驱动的影响。方法：选取30例肺功能和血气分析正常的阻塞性呼吸睡眠暂停综合征(OSAS)病人作OSAS组，选与之条件相似的30例正常人作对照组，两组均在多导睡眠检测的基础上，行中枢驱动的检查。结果：OSAS组的P0.1为0.17±0.052kPa，对照组0.13±0.048 Kpa，P＜0.05；吸入4％CO2时，OSAS组△P0.1-1为0.01±0.004 kPa，对照组△P0.1-1为0.012±0.006kPa；吸入8％CO2时，OSAS组△P0.1-2为0.049±0.012 kPa，对照组为0.058±0.019 kPa，P＞0.1。中枢驱动与分钟通气量呈正相关，有效吸气阻抗、吸气循环呈负相关；中枢驱动的反应性与睡眠暂停低通气指数(AHI)、平均氧饱和度(SaO2)呈正相关，与动脉血氧饱和度＜90％的时间占总睡眠时间的百分比(SIT90)、PaCO2、PaO2呈负相关。结论：OSAS组的中枢呼吸驱动增强，接受不同浓度CO2的刺激时，OSAS的中枢呼吸反应性正常。%Objective: To define the varition of carbon dioxide in obstructive sleep apnea syndrome. Methods : 30 obstructive sleep apnea (OSA) patients were studied in mouth occlusion pressure(P0.1). They have normal lung function and blood gas. Results: OSA patients had higher P0. 1 and normal response. There were positive correlation between P0. 1 and VT/ Ti,AHI; There were inverse correlation between P0.1 and Ti/Tot, P0. 1/VT/Ti. There were positive correlation between P0.1 and SaO2, AHI. There were inverse correlation between P0. 1 and SIT90, PaCO2, PaO2. Conclusion: OSA patients had higher center respiratory drive. Simulating central chemical receptor, there was a anormal central respiratory drive reaction with OSAS.