Obstructive Sleep Apnea-Hypopnea Syndrome: Modeling Different Diagnostic Strategies. Technology Assessment Report

摘要

Sleep Apnea is a relatively common disorder that can affect all ages. The condition is characterized by periods of disturbed airflow patterns during sleep time, namely reduced airflow (hypopnea) or airflow cessation (apnea). It is postulated that both types of airflow disturbance have similar pathophysiology and bear the same clinical significance. Obstructive sleep apnea-hypopnea syndrome (OSAHS) is the most common type of the condition (apneas and hypopneas of central and mixed central and obstructive etiology comprise the other forms). OSAHS has been associated with a variety of adverse clinical outcomes such as mortality secondary to stroke and cardiovascular events, decreased quality of life, cardiovascular disease and stroke, hypertension, diabetes and other metabolic abnormalities, as well as increased likelihood for driving and other types of accidents. The current follow-on project to the Tufts-NEMC technology assessment Home diagnosis of obstructive sleep apnea-hypopnea syndrome is a mathematical modeling of different strategies for the diagnosis of OSAHS and the subsequent titration of CPAP (for those who need the intervention).