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Diagnostic procedure apnea-hypopnea syndrome obstructive (SAHS) by quantifying the expression of phd2 and / or PHD3.
Diagnostic procedure apnea-hypopnea syndrome obstructive (SAHS) by quantifying the expression of phd2 and / or PHD3.
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机译:通过量化phd2和/或PHD3的表达来诊断阻塞性呼吸暂停低通气综合征(SAHS)。
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摘要
Diagnostic procedure apnea-hypopnea obstructive sleep syndrome (SAHS) by quantifying PHD2 expression and / or PHD3. The present invention relates to a method for the diagnosis and monitoring of treatment response apnea-hypopnea obstructive sleep (SAHS) human syndrome by quantitative determination of the expression of prolyl hydroxylase gene 3 (PHD3 = EGLN3 = HPH2) wherein the determination is performed in peripheral blood leukocytes. An alternative gene for the same purpose is the gene for prolyl hydroxylase 2 (PHD2 = EGLN1 = HPHP1). Specifically, PHD3 and PHD2 genes encoding two prolilhidroxilasas involved in degradation factor hypoxia-inducible transcription HIF (English, Hypoxia Inducible Factor-).
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