Girdin蛋白在脑胶质瘤组织中的表达及其与临床病理特征和预后的关系

摘要

Objective:To investigate the characteristics of Girdin expression and its expression in glioma patients with malignancy grade in the prognosis of these patients. Methods:Girdin expression was investigated using the SP method in glioma tissues in 100 specimens. Kaplan-Meier survival was constructed to assess Girdin expression and living status. Cox Proportional hazard analysis was used to analyze the factors affecting survival prognosis. Results:Protein expression level and pathological grade of glioma were both increased accordingly, patients with high and low protein expressions had a significantly different survival times, where patients with low Girdin expression had higher survival times as compared to patients with high Girdin expression. Cox Proportional Hazard analysis found that Girdin expression, age, pathology grade, and size of glioma were all factors affecting the prognosis of glioma patients. Conclusion:Expression of the protein Girdin is positively correlated with pathological grade of gliomas, and patients with high Girdin expression have poorer prognosis, suggesting that Girdin may play a role in tumor genesis and progression of gliomas.%目的:研究Girdin在人脑胶质瘤组织中表达的特点及其与病理特征和预后的关系. 方法:应用SP免疫组化技术测定100例脑胶质瘤组织中Girdin的表达情况,分析Girdin表达与患者临床病理特征的关系,Kaplan-Meier生存曲线分析Girdin表达与预后的关系,用Cox比例风险分析影响生存结果的独立预后因素. 结果:Girdin在各病理级别脑胶质瘤中均有表达,Girdin在III~IV级脑胶质瘤表达高于Ⅰ~Ⅱ级脑胶质瘤,差异具有统计学意义. Girdin表达与脑胶质瘤恶性程度、肿瘤大小呈正相关,Girdin高表达组患者的预后比低表达组患者差,Cox比例风险分析提示Girdin、年龄、病理学分级及肿瘤大小是脑胶质瘤患者预后影响因素. 结论:Girdin可能在促进恶性脑胶质瘤发生发展中起重要作用.