合成了3种新型芳基吡唑酮(1-苯基-3-甲基-4-乙酰基-5-吡唑啉酮、1-苯基-3-甲基-4-甲酰-5-Cl-吡唑和苯甲酰丙酮)缩4-氨基安替比林席夫碱,对合成的化合物进行了元素分析、光谱分析(红外和紫外)以及HNMR分析。采用纸片扩散法,测试了化合物对大肠杆菌和枯草芽孢杆菌的抗茵活性。结果表明,所有化合物都有一定的抑制大肠杆菌和枯草芽孢杆菌生长的活性。%Three new Schiff bases derived from Ll (where L1=l-phenyl-3-methyl-4-acetyl- 5-pyrazolone, 1 -phenyl-3-methyl-4-formyl-5-Cl-pyrazole and benzoylacetone) and 4- Amino antipyrine have been prepared and characberized by elemental analysis, spectroscopic data (IR and UV) and HNMR. The antibacterial activity tests of the compounds at different concentrations against Bacillus coli and Bacillus subtilis were performed by using disc diffusion method. The reaults indicate that almost all compounds have the activity of inhibiting the growth of the two bacteria.
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