The newly created knowledge, leading the development of science and technology, is the power source of the future economic and social development. Due to the lack of a long time market test, however, the costs and risks in the early application of this kind of knowledge are so high that it is very difficult for enterprises in cluster to take the initiative to accept. On the basis of related literature review, this paper illustrates the basic hypothesis of cluster knowledge system, builds a cluster knowledge diffusion model with government involved based on epidemic model. Through mathematical derivation it is found that regardless of the propagation and regeneration of existing knowledge in several industrial clusters, the government's macroeconomic regulation and control and incentive policy will promote cluster in promotion and application of new knowledge and speed up the leap-upgrading of knowledge system in a cluster. In the end, the paper puts forward the policy recommendations of promoting newly created knowledge within clusters.%引领科技发展的新创知识虽然是未来经济社会发展的动力源泉，但由于缺乏市场的长期检验，这类新创知识早期应用成本和风险均较高，导致集群企业很难主动接受。文章在相关文献综述的基础上，阐释了集群知识系统运行的基本假设，构建了一个基于传染病模型的政府参与的集群知识扩散模型，通过数理推导发现，无论产业集群内现存知识的传播再生数多大，政府宏观调控和激励政策在集群内新创知识推广和应用过程中的作用显著，能够加快集群内知识系统的跨越式升级，最后文章提出了促进集群内新创知识应用的政策建议。
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