茶多酚对阿尔茨海默病的防治功能与机理研究进展

摘要

阿尔茨海默病作为一种神经退行性疾病，因与认知功能相关的神经元异常而导致记忆衰退，甚至影响自主行动和吞咽。茶多酚能够有效防治阿尔茨海默病，其机制主要包括阻碍异常蛋白积累、抗氧化、影响神经递质水平、调节细胞信号转导通路及抗炎等。本文就近年来茶多酚对阿尔茨海默病的防治功能与机理方面的研究进行综述。%Alzheimer's disease, a kind of neurodegenerative disease, is caused by the abnormal neurons associated with cognitive function, which can lead to the decline of memory, even affect the independent action and swallow. It has been reported that tea polyphenols showed positive effects on Alzheimer's disease by inhibiting the accumulation of abnormal proteins, antioxidative, modulating neurotransmitter levels, regulating cell signaling pathways and anti-inflammatory, etc. In the present paper, the prevention of tea polyphenols on Alzheimer's disease was summarized, and their mechanisms were discussed as well.