热休克蛋白 90调节内皮一氧化氮合酶 (一个新近认识的心血管疾病调节物 )

摘要

阐述热休克蛋白 90( hsp90)作为一个心血管疾病新的调节物,在调节内皮一氧化氮合酶( eNOS)功能方面的作用:血管内皮一氧化氮( NO)主要来源于 eNOS; eNOS同时有产生 NO和氧阴离子自由基(O2)的功能. NO与(O2)的平衡在调节心血管方面有着重要的作用,当这个平衡被打破时可导致多种心血管疾病的发生发展;实验发现,当 hsp90与 eNOS结合增加时, eNOS耦联产生 NO,当 hsp90与 eNOS结合减少或结合后无发生结构改变时 eNOS非耦联产生(O2) .进而提出深入探讨 hsp90调节 eNOS机制的必要性.%The aim of this article was to illustrate the effect of regulation of endothelial nitric oxide synthase (eNOS) by heat shock protein 90 (hsp90), a newly recognized player in cardiovascular diseases. eNOS is the major source of nitric oxide (NO) in vascular endothelial cells. eNOS has two activities, producing NO and generating superoxide anion (O2). The balance between NO (O2) and may play important roles in regulating cardiovascular system. Disturbances in this balance may lead to many cardiovascular diseases. When increase of hsp90 associated with eNOS, eNOS couples and generates NO, when decrease of hsp90 associated with eNOS or no changes on hsp90 conformation after associated with eNOS, eNOS uncouples and generates (O2). It is necessary to understand how hsp90 regulates eNOS in the future.