高血压患者检测颈动脉内膜中层厚度、动脉硬化指数、血纤维蛋白原的临床意义

摘要

Objective To investigate the relationship of the intima-media thickness of carotid artery ( IMT) and blood pressure , blood lipid,atherosclerosis index (ASI) and fibrinogen (FIB)in patients with essential hypertension.Methods 140 cases of hyper-tensive patients were Selected from January 2011 to June 2013 as the research object ,According to the results of carotid ultrasound examination,140 cases were divided into IMT group (61 cases),thickening of artery plaque group (47 cases) and control group (22 cases).The differences of 3 groups of blood pressure ,blood fat,ASI,FBI and other index were observed.Results TC,LDL-C,ASI and FIB gradually decreased in the arterial plaque group ,thickening of IMT group and normal group ,HDL-C increased in the three groups.Comparison between groups had significant difference ( P<0.01 ) .Conclusion the IMT of carotid artery increasing and plaque formation leaded to the TC ,LDL-C,ASI and FIB of Blood pressure patients increasing ,and the HDL-C decreasing.These fac-tors can be used as an index for determining the degree of atherosclerosis in patients .%目的：探讨高血压患者颈动脉内膜中层厚度（ IMT）与血压、血脂、动脉硬化指数（ ASI）及血纤维蛋白原（ FIB）的关系。方法选取2011年1月～2013年6月期间140例高血压患者为研究对象，根据颈动脉超声检查结果分为IMT增厚组（61例）、动脉斑块组（47例）及正常组（22例）。观察3组患者的血压、血脂、ASI、FBI等指标的差异。结果 TC、LDL-C、ASI及FIB在动脉斑块组、IMT增厚组及正常组中逐渐下降，HDL-C在3组中逐渐升高，组间比较均有显著差异（P＜0.01）。结论高血压患者的TC、LDL-C、ASI及FIB随着颈动脉IMT的增加及斑块形成而上升，HDL-C则随之下降，这些因子可作为判定患者动脉硬化程度的指标。