老年退行性疾病中Caspase非依赖性细胞凋亡机制研究

摘要

细胞凋亡是一种程序化的主动的细胞死亡过程。一般认为它是由蛋白酶Caspase通过两种途径激活的。但最近的研究发现除了Caspase引起的凋亡外，还有Caspase非依赖性的细胞死亡形式存在。本文综述了近年来有关Caspase非依赖性细胞凋亡调控的研究进展。%Apoptosis is an active form of cell death enabling individual cells to commit suicide .Which it is generally considered by the protease Caspase activation via two pathways .However , an increasing number of studies substantiate the existence of Caspase -independent forms of PCD .This paper reviews the research progress of the Caspase-independent apoptosis regulation in recent years .