帕金森病认知功能障碍的量表评估及相关危险因素分析

摘要

Objectives To study the application of Montreal cognitive assessment ( MoCA ) and mini-mental state examination (MMSE) in screening cognitive impairment in Parkinson ’s disease(PD) patients,and analyze related risk factors of PD cognitive im-pairment.Methods One hundred and twenty PD patients were divided into normal group (PD-NCI),mild cognitive impairment group(PD-MCI) and PD dementia group (PDD) according to their cognitive function.They were assessed and according to their Mo-CA and MMSE score, and to analyze the relationship between related risk factors of gender , age, years of education, the course of the disease and cognitive impairment .Results The MoCA and MMSE scores were significantly different in 3 groups ( P<0.05 ) . Compared with normal group , MCI and PDD group have less education and more elderly male patients ( P<0.05 ) .Conclusions MoCA combined MMSE is effective in screening the cognitive impairment in Parkinson ’s disease patients.Gender, age, level of educationand course may be related risk factors of PD cognitive impairment .%目的：探讨蒙特利尔认知评估量表（MoCA）和简易智能状态检查量表（MMSE）在筛查帕金森病（PD）患者认知功能障碍中的应用，同时分析PD认知功能障碍的相关危险因素。方法分析我院120例PD患者，根据认知功能将其分为正常组（PD－NCI，60例）、轻度认知功能障碍组（PD－MCI，32例）和PD痴呆组（PDD，28例），采用MoCA和MMSE对患者进行评估，同时分析性别、年龄、受教育年限，病程相关因素与PD认知功能障碍的关系。结果三组MoCA、MMSE得分差异有统计学意义（ P＜0．05）。与正常组比较，受教育程度低的老年男性PD患者似乎更易出现MCI及PDD。结论 MoCA结合MMSE可有效筛查PD患者认知功能损害。性别、年龄、受教育程度及病程可能是PD认知功能障碍的相关危险因素。