年龄对正常人脑边缘区功能连接的影响

摘要

Objective To investigate the age-related changes in resting functional connectivity of the marginal division (MrD) of the neostriatum in healthy adults detected using resting-state functional magnetic resonance imaging (rs-fMRI). Methods Forty-four healthy volunteers aged between 22 and 44 years (mean 30.36±6.31 years) and 20 elderly volunteers aged between 48-83 years (mean 61.4±10.25 years) underwent conventional MRI, 3D structural MRI and rs-fMRI. MrD was denned manually on the structural images for computation of the functional connectivity maps. The single group data were analyzed with independent sample t test, and the data of the two-group were examined by analysis of covariance with gender as the covariance. Results In the young volunteers, the brain regions of functional connectivity related with the MrD were located in bilateral middle cingulate gyri, putamen, thalamus and amygdala, as compared with the brain regions of the bilateral putamen, thalamus, amygdala, insular cortex, rolandic operculum and right supramarginal gyrus in the elderly volunteers. Compared with the young volunteers, the elderly volunteers showed decreased functional connectivity related with the MrD in the bilateral middle cingulate gyri, parahippocampal gyri and left hippocampus. Conclusion An increased age is associated with alterations in the functional connectivity related with the MrD in healthy adults.%目的 采用静息态功能磁共振成像研究年龄对正常人脑边缘区功能连接的影响.方法 对64名健康志愿者进行常规MRI、三维结构像及静息态脑功能成像扫描.将受试者分为年轻组及年老组,并手工勾画边缘区蒙片,进行全脑基于感兴趣区的功能连接计算.单组数据采用单样本t检验,成组数据采用协方差分析,性别为协变量.结果 年轻组边缘区相关的功能连接位于双侧中扣带回、壳核、丘脑及杏仁核；年老组边缘区相关的功能连接脑区位于双侧壳核、丘脑、杏仁核、岛叶、岛盖及右侧缘上回.年老组较年轻组边缘区相关的功能连接减少脑区主要位于双侧中扣带回、海马旁回及左侧海马.结论 年龄增加可致边缘区功能连接改变.