血清载脂蛋白B、载脂蛋白B/载脂蛋白A1值与冠状动脉病变的相关性分析

摘要

目的:研究血清载脂蛋白B(ApoB)、载脂蛋白B/载脂蛋白A1(ApoB/ApoA1)值与冠脉粥样硬化病变及其严重程度的关系.方法:500例行冠脉造影检查的住院患者根据冠脉造影结果分为冠心病组(CHD组,206例)和对照组(294例),比较血清ApoB、ApoB/ApoA1值在两组中的变化,分析ApoB、ApoB/ApoA1值与颈动脉内中膜厚度(IMT)、冠脉病变支数及狭窄严重程度的相关性.结果:CHD组血清ApoB[(1.02±0.25) vs (0.86±0.22)g·L-1,P＜0.05]和ApoB/ApoA1值(0.94±0.50 vs 0.78±0.21,P＜0.05)显著高于对照组;ApoB(r=0.46,P＜0.01)、ApoB/ApoA1值(r=0.52,P＜0.01)与IMT呈显著正相关,与冠脉病变支数(ApoB:r=0.29,P＜0.05;ApoB/ApoA1:r=0.42,P＜0.01)及狭窄程度(ApoB:r=0.32,P＜0.01;ApoB/ApoA1:r=0.38,P＜0.01)亦呈显著正相关.结论:ApoB、ApoB/ApoA1值与冠心病发病及冠脉病变程度密切相关,反映了动脉粥样硬化的程度.%Objective: To investigate the correlation of serum apolipoprotion B( ApoB ) levels and apolipoprotion B/apolipoprotion A1( ApoB/ApoA1 ) ratio with coronary heart disease( CHD ).Methods: A total of 500 hospitalized patients were divided into CHD group( n =206 ) and control group( n =294 ), according to the results of coronary angiography( CAG ).The changes of serum ApoB levels and ApoB/ApoA1 ratios were investigated between CHD and the control group.Correlation and regression analysis were applied to find the correlation between serum ApoB levels, ApoB/ApoA1 ratio and the carotid IMT, the vessels narrowed and narrowing degree in CHD.Results: ApoB[( 1.02 ±0.25 )vs (0.86 ±0.22 )g· L-1, P ＜ 0.05]ApoB/ApoA1 ratio( 0.94 ± 0.50 vs 0.78 ±0.21, P ＜ 0.05 )were significantly higher in CHD group than in the control group, the ApoA1 changed inversely;Correlation analysis showed that ApoB( r=0.46,P ＜ 0.01 ), ApoB/ApoAl( r=0.52, P ＜ 0.01 ) ratio were positively correlated to the carotid IMT.Among patients with CHD, ApoB, ApoB/ApoA1 were also positively correlated to the narrowing vessel number( ApoB: r = 0.29, P ＜ 0.05; ApoB/ApoA1: r = 0.42, P ＜ 0.01 ) and the narrowing degree( ApoB:r =0.32, P ＜0.01; ApoB/ApoA1 :r =0.38,P ＜0.01 ).The positive correlation was found with ApoA1.Conclusion: The Serum ApoB levels, ApoB/ApoA1 ratio are significantly correlated with CHD, reflecting the severity of CHD and the degree of atherosclerosis, which indicates extent of coronary lesions.