感染与支气管哮喘发病机制的相关研究进展

摘要

支气管哮喘（简称哮喘）的发病机制尚未明确，由嗜酸性粒细胞、肥大细胞、 T淋巴细胞、中性粒细胞、平滑肌细胞、气道上皮细胞等多种细胞和细胞因子导致的气道炎症改变、气道高反应性、气道重构、黏液高分泌等机制已得到普遍认可。呼吸道感染与哮喘发病和病情加重存在重要关系，但其机制仍不十分明确。因此对其关系的研究具有重要意义，可为哮喘发病早期防治提供新思路。%The pathogenesis of bronchial asthma ( asthma) is not yet clear. Asthma is characterized by chronic airway inflamma⁃tion, airway hyperresponsiveness, airway remodeling and mucus hypersecretion, which are induced by eosinophils, mast cells, T lymphocytes, neutrophils, smooth muscle cells, and airway epithelial cells. Respiratory infection plays an important role in the inci⁃dence of asthma, but the pathogenesis can not be explained clearly. So the relationship between respiratory infection and asthma is important. This will provide a new way of early prevention and treatment of asthma.