血必净注射液治疗重症急性胰腺炎临床疗效观察

摘要

Objective To observe the clinical efficacy of Xuebijing injection for severe acute pancreatitis( SAP ). Methods Seventy-three patients with SAP were divided into experiment group and control group according to the treatment. Conservative treatment was given in control group. Based on the treatment in control group,Xuebijing injection was additionally injected twice a day in experiment group for 7 d continuously. The time of relieving the abdominal pain and distension, the time of evacuation and the body temperature in two groups were observed. White cell count,blood and urine amylase,blood calcium and coagulation function before therapy and 1,3 ,7 d after therapy,and clinical curative effects were also recorded. Results The total effective rate and the curative rate in experiment group were significantly higher than those in control group( P <0.05 ). The white cell count,levels of blood and urine amylase at 3 ,7 d and blood glucose at 7 d were significantly decreased in experiment group, and blood calcium increased, and coagulation function were improved. The time of relieving abdominal pain and distension, and the time of evacuation were shorter than those in control group( P < 0.05 ) The incidence of complication and the recovery time of body temperature in experiment group were lower than those in control group,but there was no significant difference( P >0. 05 ). Conclusion Xuebijing injection is effective to treat SAP.%目的 观察血必净注射液治疗重症急性胰腺炎的临床疗效.方法 我院2009-01～2011-10普外科收治的资料完整的SAP病例共73例,分为实验组和对照组做回顾性分析.对照组给予保守治疗;实验组加用血必净注射液.观察两组腹痛、腹胀缓解时间、排气时间、体温恢复时间;入院时、经治疗后第1,3,7天的白细胞计数、血尿淀粉酶、血钙、血糖变化,凝血功能变化,预后及疗效水平.结果 实验组腹痛、腹胀缓解时间、排气时间较对照组明显缩短(P<0.05).实验组治疗第3,7天后白细胞计数、血尿淀粉酶、血糖(第7天)水平明显下降,血钙水平升高,凝血功能各项指标较对照组有改善,总有效率高于对照组(P<0.05).体温恢复时间较对照组缩短,感染及并发症发生率低于对照组,但差异无统计学意义(P>0.05).结论 血必净能明显缩短SAP患者腹痛/腹胀、恢复排气时间,降低WBC、血尿淀粉酶,升高血钙水平,改善凝血功能等各项实验室指标,促进患者症状、体征的恢复,提高治疗效果.