Objective To evaluate the value of" F-FDG PET-CT and HRCT in the diagnosis and staging of the lung cancer. Methods Clinical data of 65 cases of lung cancer confirmed by operation and pathology, were analyzed retrospectively. The relationship between PET-CT imaging features and pathological typies, and between tumor size and SUVmax were analyzed. Statistical analysis was performed using bivariate correlation analysis. Twenty-three cases were scanned at 1 h after routine scanning,and retention index(RI) of FDG was calculated. Results In 65 cases of lung cancer, the diagnostic sensitivity of PET-CT was 100% , and the diagnostic specificity was 93.8%. The diagnostic sensitivity of HRCT and PET were 96.9% and 93.8% respectively,and the diagnostic specificities were 72.3% and 90.7% .respectively. The main PET-CT characteristics of primary lesions were nodules or masses in lungs in 61 cases .and the mean SUVmax was 9.78 ±5.63. Four cases of bronchioalveolar carcinomas manifested the glass opacity,and the mean SUVmax was 0.91 ±0. 14. Mean SUVmax of delayed scanning in solitary pulmonary nodule was 11.76 ±5.40,and RI was (39.31 ±3.62)%. The SUVmax of tumor was positively correlated with the tumor size (r = 0.51, t = 4.56, P < 0.000 5 ). Conclusion Dual time point PET-CT combining with HRCT is proved to be more effective than any single diagnostic technique for accurately detecting and staging the lung cancer.%目的 分析肺癌18F-FDG PET-CT与HRCT的表现并探讨其在诊断及分期方面的价值. 方法 回顾分析65例经病理证实肺癌的PET-CT与HRCT资料并与其病理分型作对照,分析肿瘤大小与SUVmax关系,统计学方法采用双变量相关分析；其中23例常规扫描后1h行延迟扫描,计算滞留指数(RI). 结果 对于65例肺癌患者中原发灶的检出,PET-CT敏感性100％,准确性93.8％；肺部HRCT敏感性96.9％,准确性72.3％；PET敏感性93.8％,准确性90.7％.肺癌中61例为实性结节或软组织肿块,SUVmax为9.78 +5.63;4例细支气管肺泡癌为磨玻璃灶,SUVmax为0.91±0.14;肺孤立结节(SPN)延迟扫描SUVmax为11.76±5.40,SUVmax升高值为3.2±1.3,RI为(39.31±3.62)％.实性原发灶SUVmax与肿瘤大小呈正相关(r=0.51,t =4.56,P＜0.000 5). 结论 PET-CT双时相扫描结合HRCT对肺癌性质判断及分期具有重要的价值.
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