不同营养状态儿童血浆orexin-A水平与能量摄入的相关性

摘要

Objective To explore the changes of plasma orexin -A concentration and its correlation with energy intake in children with different nutritional status.Methods A total of 42 malnourished children ,42 ohese children and 42 healthy children were enrolled in this study.Peripheral blood orexin -A concentrations , BMI and energy intake were detected , and the correlations between orexin -A and BMI, energy intake were analyzed.Results The plasma orexin-A level in malnourished children was significantly higher than that in controls (P <0.05).Plasma orexin-A concentration was negatively related with BMI and carbohydrate in malnourished children , and positively related with total energy intake ,fat intake and protein intake.The plasma orexin-A level in obese children was lower than that in controls(P <0.05).Plasma orexin-A concentration was negatively related with BMI and carbohydrate in obese children ,and positively related with total energy intake , fat intake and protein intake.Plasma orexin-A concentration was negatively correlated with BMI in control group, but positively with total energy intake , fat intake , protein intake and carbohydrate.Conclusion Orexin-A is involved in the regulation of nutritional status in children , and the interaction between plasma orexin -A and energy intake might be different in chil -dren with different nutritional status.%目的 探讨不同营养状态儿童血浆增食欲素-A水平改变及其与能量摄入的相关性.方法 检测42例营养不良组儿童和42例肥胖组儿童空腹外周血中orexin-A水平、体质量指数(BMI)和能量摄入量,并与42例性别、年龄匹配的健康儿童(健康对照组)进行比较,分析orexin-A与BMI、能量摄入的相关性.结果 营养不良组儿童血浆orexin-A水平显著高于健康对照组(P<0.05),且orexin-A水平与BMI呈负相关,与总能量、脂肪、蛋白质摄入量均存在正相关,与碳水化合物摄入量呈负相关;肥胖组儿童血浆orexin-A水平显著低于健康对照组(P<0.05),且orexin-A水平与BMI呈负相关,与总能量、脂肪、蛋白质摄入量均呈正相关,与碳水化合物摄入量呈负相关;对照组儿童血浆orexin-A水平与BMI呈负相关,与总能量、脂肪、蛋白质和碳水化合物摄入量均存在正相关(P<0.05).结论 Orexin-A参与了机体营养状态的调节,orexin-A与能量摄入存在相关性,且在不同的营养状态下作用不同.