肾功能正常冠心病患者血肌酐与冠脉病变严重程度的关系

摘要

目的 探讨肾功能正常冠心病患者血清肌酐(serum creatinine,SCr)水平与冠状动脉病变严重程度的关系. 方法 选择274例通过冠状动脉造影确诊为冠心病且肾功能正常的患者为冠心病组,同期住院行冠状动脉造影排除冠心病且肾功能正常者共47例为对照组,测定两组的各项生化指标,分析两组间一般资料的差异.方差分析比较不同类型冠心病、不同病变支数和不同病变程度冠心病分组中SCr水平的差异. 结果 冠心病患者SCr水平较对照组显著升高(P=0.000),且随着冠心病类型的严重度、病变支数及病变狭窄程度增加而增加(P=0.018,0.038,0.023). 结论 肾功能正常患者SCr水平与冠状动脉病变严重程度呈正相关关系,SCr水平对冠心病的诊疗具有一定的临床价值.%Objective To explore the correlation between serum creatinine level and the severity of coronary artery disease in patients with normal renal function.Methods Totally 274 patients with normal renal function and coronary heart disease diagnosed by coronary angiography were selected as coronary heart disease group,and 47 patients with normal renal function and non-coronary heart disease were selected as control group at the same period.The biochemical indexes in the two groups were measured and compared.The creatinine levels were compared in different types of coronary heart disease(CHD),different numbers of diseased vessels and different lesions by ANOVA.Results The serum levels of creatinine was significantly higher in coronary heart disease group than in control group(P =0.000).The level of serum Cr in patients with coronary heart disease increased with the increase of the severity (P =0.018),lesion numbers (P =0.038) and lesion degree of coronary artery disease (P =0.023).Conclusion The level of serum creatinine is positively correlated with the severity of coronary artery disease in patients with normal renal function.It has clinical value in the diagnosis and treatment of coronary heart disease.