Retrospective Review of Serum Creatinine and Creatinine-Based Measures of Estimated Glomerular Filtration Rate in an Amputee Population.

摘要

A variety of equations are used to estimate glomerular filtration rate (eGFR). These formulas have never been validated in the setting of traumatic amputation. In this retrospective study involving 255 military personnel with traumatic amputations, muscle mass lost was estimated using percentage of estimated body weight lost (% EBWL). Serum creatinine (Scr) and eGFR by the Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations were compared to % EBWL for each patient. Percentage EBWL has a significant correlation with Scr and eGFR by both the MDRD and CKD-EPI equations. Furthermore, patients with traumatic amputation have significatly lower Scr values than the general population. Cretinine-base estimates of GFR may overestimate renal function in the setting of traumatic ampuation.