Objective To study the effects of argon plasma coagulation combined with Rabeprazole on Barrett' s esophagus. Methods Totally 181 patients with Barrett' s esophagus diagnosed by endoscope and pathological method were randomized into three groups: group A (n= 56) were treated with Rabeprazole; group B (n= 60) were treated with argon plasma coagulation and group C (n= 65 ) were treated with argon plasma coagulation combined with Rabeprazole. All the patients were rechecked by endoscope and pathological method within 3,6 and 12 months after treatment. Results The follow-up went within 3,6 and 12 month after the first treatment. The total effective rates in group A were 5.4％ ,4.9％ ,3. 1％ respectively; those of group B were 85.0％ ,82.4％ ,85.4％ respectively and those of group C were 90.8％ ,92.5％ ,91.5％ respectively. There were statistical differences between groups(P ＜ 0.05). Conclusion Argon plasma coagulation combined with Rabeprazole in the treatment of Barrett' s esophagus is effective and safe and is worth applying and extending in clinics.%目的 探讨内镜下氩离子凝固术联合雷贝拉唑治疗Barrett食管疗效.方法 选择经电子胃镜检查及病理组织学检查确诊为Barrett食管患者181例,随机分成3组,A组(56例)为单纯雷贝拉唑治疗组;B组(60例)为单纯内镜下氩离子凝固术治疗组;C组(65例)为内镜下氩离子凝固术联合雷贝拉唑治疗组.所有入选患者在首次治疗的3、6、12个月内随访复查内镜及病理组织学检查.结果 A、B、C三组在首次治疗的3、6、12个月内随访,A组总有效率分别为5.4%、4.9%、3.1%;B组总有效率分别为85.0%、82.4%、85.4%;C组总有效率分别为90.8%、92.5%、91.5%.以上两两组间比较均有统计学意义(P<0.05).结论 内镜下氩离子凝固术联合雷贝拉唑治疗Barrett食管是安全有效的,值得临床推广与应用.
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