降钙素原在抗感染治疗中的动态变化研究

摘要

Objective To assess the value of procalcitonin( PCT) in anti-infective therapy by observing PCT concentration change in therapy. Methods Sixty-eight patients with bacterial infection meet the diagnostic criteria were divided into effective group and invalid group,the PCT level on day 1,day 3,day 5 and day 7 were observed respectively. Results PCT concentrations of two groups showed no sig-nificant difference on day 1. The PCT level of effective group gradually declined and PCT level of invalid group gradually rised with significant difference on day 3,day 5 and day 7(P<0. 05). Conclusion PCT level that is positively correlated with inflammation of infectied patients, which can be used as an effective indicator to optimize antibiotic therapy.%目的：观察血清降钙素原( PCT)在细菌感染治疗中的动态变化，评估PCT在抗感染治疗中的应用价值。方法回顾性分析2013年6月至2014年4月我院68例细菌感染患者的临床资料，根据对抗生素的最终疗效分为抗生素有效组和抗生素无效组，观察2组患者治疗第1天、第3天、第5天及第7天血清PCT水平。结果2组患者入院第1天血清PCT浓度差异无统计学意义，第3天、第5天及第7天抗生素有效组血清PCT水平逐渐下降，抗生素无效组血清PCT水平逐渐升高，组间比较差异有统计学意义(P<0.05)。结论血清PCT水平与感染患者的炎症程度呈正相关，监测PCT变化可以更合理地使用抗生素。