肺癌患者化疗前后血浆leptin和血清Hcy、NPY检测的临床意义

摘要

目的:探讨肺癌患者化疗前后血浆leptin和血清Hcy、NPY水平的变化及临床意义.方法:应用放射免疫分析和化学发光法对36例肺癌患者进行了血浆leptin和血清Hcy、NPY测定,并与35名正常健康人作比较.结果:肺癌患者在化疗前血浆leptin和血清Hcy、NPY水平均非常显著地高于正常人组(P<0.01),化疗后6个月在未复发的28例中明显下降或接近正常,而复发的8例,其数值又回升至化疗前水平(P<0.01).结论:检测肺癌患者血浆leptin和血清Hcy、NPY水平的变化可作为诊断和疗效观察的参数.%Objective To explore the changes of plasma leptin and serum Hcy, NPY levels before and after chemotherapy in patients with lung cancer. Methods plasma leptin and serum NPY(with RIA) , serum Hcy(with CLIA) levels were determined in 36 patients with lung cancer both before and after chemotherapy as well as in 35 normal healthy controls. Resu Before chemotherapy plasma leptin and serum Hcy, NPY levels in the patients were significantly higher than those in controls(P <0.01) . After chemotherapy in 28 cases without recurrence at 6 months the levels remained dropped markedly and approached those in controls. However in 8 patients with recurrence, the levels increased again, approaching those before chemotherapy. Conclusion plasma leptin and serum Hcy,NPY levels might be useful as a parameter for diagnosis and predicting therapeutic effects after chemotherapy in patients with lung cancer.