DM2患者微血管病变时测定血浆ET、hs-CRP和TNF-α水平的临床意义

摘要

目的:为了探讨2型糖尿病(DM2)患者微血管病变时测定血浆ET、hs-CRP和TNF-α水平的临床意义.方法:ET、hs-CRP和TNF-α测定均采用放射免疫分析,并与65例正常对照组进行了对比性分析.结果:126例DM2患者的血浆ET、hs-CRP和TNF-α水平均非常明显地高于正常对照组(P均＜0.01)；50例伴有微血管病变的DM2患者血浆ET、hs-CRP和TNF-α水平明显高于不伴有微血管病变的DM2患者(P分别为＜0.05、＜0.01和＜0.01)和非常明显高于正常对照组(P＜0.001).表明:血浆ET、hs-CRP和TNF-α水平随DM2的严重程度而增高.结论:血浆ET、hs-CRP和TNF-α水平是诊断DM2患者或早期发现DM2微血管病变的有效指标.%Objective To explore the clinical significance of determining plasma ET,hs-CRP and TNF-a levels in type 2 diabetes patients with microvascular disease. Methods Plasma ET,hs-CRP and TNF-a levels(with radioimmunoassay.RIA) were determined in 126 patients with type 2 diabetes. 126 patients with type 2 diabetes were divided into two groups, one group was composed of 76 type 2 diabetics without microvascular disease, other group was SO type 2 diabetics with microvascular disease. Compared with 65 normal controls and analysed. Results The levels of plasma ET,hs-CRP and TNF-a in 126 patients with type 2 diabetes were significantly higher than those in normal controls(P all <0.01). The levels of plasma ET,hs-CRP and TNF-a in 50 type 2 diabetes patients with microvascular were extremely higher than those in 76 type 2 diabetics patients (P<0.05, <0.01 and <0.01,respectively) and dramatically higher than those in 65 normal controls ( P all < 0.001). It indicated the plasma ET, hs-CRP and TNF-a levels were increased with the severity of type 2 diabetics. Conclusion The plasma ET,hs-CRP and TNF-a levels might be helpful indices in diagnosis of type 2 diabeties and to trace type 2 diabetes patients with microvascular disease earlier.