慢性乙型肝炎患者血清TGF-β、CTGF、HA和PⅢP检测的临床意义

摘要

Objective To investigate the significance of changes of 8eruln TGF-β,CTGF,HA and PⅢP levels in patients withchronic hepatitis B.Methods Serum TGF-β,HA,PⅢP(with RIA),serum CTGF(with ELISA)levels were measured in 36 cases ofpatients with hepatitis B,35 normal controls.Results Serum TGF-β,CTGF,HA and PⅢP levels were significantly higher than those incontrols(P<0.01).Serum TGF-β were positively correlated with the CTGF,HA and PⅢP levels(r=0.6018,0.5784,0.5584,P<0.01).Conclusion Detection of serllnl TGF-β,CTGF,HA and PⅢP in the patients with chonic hepatitis B provided importantclinical values.The changes of such biomarkers Can be improved to recoglize the process and prognostic evaluation of the出sease%目的:探讨了慢性乙型肝炎患者血清TGF-β、CTGF、HA和PⅢP的水平变化及其临床意义.方法:应用放射免疫分析和酶联法对36例慢性乙型肝炎患者进行了血清TGF-β、CTGF、HA和PⅢP检测,并与35名正常健康人作比较.结果:慢性乙型肝炎患者血清TGF-β、CTGF、HA和PⅢP水平均非常显著地高于正常人组(P＜0.01).且血清TGF-β水平与CTGF、HA、PⅢP水平呈正相关(r=0.6018、0.5784、0.5584,P＜0.01).结论:检测慢性乙型肝炎患者血清TGF-β、CTGF、HA和PⅢP的水平具有重要的临床价值,这些生物标志物的变化,可提高对病情及预后评估的认识.