CA125、Tg联检在甲状腺良、恶性肿瘤的临床意义

摘要

Objective To explore the expression levels of serum carbohydrate antuenl25 (CA12S) and Tg in patients with be nign and malignant thyroid tumors. Methods Serum CA12S level was detected with immunoradiometiic assay (IRMA) , serum Tg level was detected with radioimmunoaasay(RIA)in 36 patients with differentiated thyroid carcinomas (10men,26women,average age 43.5 ±33. 5y) , 23 patients with benign thyroid tumors(10men,13women, average age 40.0 ±24. 0y) and 30 normal controls( 13men, 17women, average age 59.0 ± 19.0y) simultaneously. All patients without other tumor histories, all females were no sign of pregnancies, ovulations, menstrual periods,gynecological inflammations and tumors. Data analysis was performed with the SPSS13.0 statistic software. Results The expression level of serum CA125 in DTC 14.09 ( detecting rang 1.00～215. 35)U/ml was evidently higher than the benign thyroid tumors 7.33(detecting rang 3.63～24.13 )U/ml, P<0.05), the level of serum Tg in benign and malignant thyroid tumors 4.48(detecting rang 1.20～22.02) μg/l, 4. 82(detecting rang 1.21 ～26.14) μg/L) respectively, compared to the normal controls 3.22[ (detecting rang 0.07～16.46) μg/L, P<0.05 )] showed statistical significance . The expression level of serum CA125 showed positive relation with the stage of the malignant thyroid glands (r=0.490,P<0.05). The higher expression level of serum CA125 related to higher stage of the malignant tumors. Conclusion The expression level of serum CA125 was associated with malignant thyroid tumors but also the higher stage classification of differentiated thyroid carcinoma. The expression level of serum Tg keep the relationship with thyroid tumors,but it can not be used for differentiating benign tumors from malignant ones and also manifest no relation with the stage of differentiated thyroid carcinoma.%目的:探索联检血清CA125和Tg在甲状腺良、恶性肿瘤中的表达水平,评价CA125在甲状腺良、恶性肿瘤中的临床意义.方法:对36例甲状腺肿瘤恶性组、23例甲状腺肿瘤良性组和30例正常对照组分别采用免疫放射分析(IRMA)测定血清CA125和放射免疫分析法(RIA)测定血清Tg并分析其结果,所有对象无甲状腺疾病以外的肿瘤病史,女性排除妊娠、排卵期、月经期、妇科炎症及肿瘤征兆.结果:甲状腺恶性组的血清CA125水平14.09(范围1.00～215.35) U/ml与甲状腺良性组CA125水平7.33(范围3.63～24.13)U/ml差异有统计学意义(P<0.05);甲状腺恶性组Tg水平4.48(范围1.20~22.02)μg/L和良性组的血清Tg水平4.82(范围1.21~26.14)μg/L均高于正常对照组3.22(范围0.07~16.46)μg/L,P<0.05);甲状腺恶性组不同病理期别的CA125差异有统计学意义(r=0.490,P<0.05),病理期别与CA125水平呈正相关,病理期别高者,CA125水平较高.结论:血清CA125水平与甲状腺肿瘤的恶性和病理分期有关,血清Tg水平可反映是否存在甲状腺肿瘤,但无法鉴别肿瘤的良、恶性,其与病理分期无关.