131I治疗分化型甲状腺癌术后肺转移的临床研究

摘要

目的:探讨放射性131I治疗分化型甲状腺癌(differentiated thyroid cancer,DTC)术后肺转移的临床疗效和不良反应.方法:回顾性统计分析我院10年来32例采用131I治疗的DTC术后肺转移患者,观察他们在治疗前后131I全身显像、颈胸CT、血清甲状腺球蛋白(Tg)的变化,同时观察他们的外周血以及肝肾功能在治疗前、后的变化.结果:应用131I治疗DTC术后肺转移的总有效率达到84.4%,且该方法对患者外周血的各类细胞、血红蛋白以及肝肾功能均无明显影响.结论:应用131I治疗DTC术后肺转移疗效好、不良反应小,是一种行之有效的临床治疗方法.%Objective To investigate the clinical efficiency and side effect of 131 I atment of differentiated thyroid cancer (DTC) with lung metastases. Methods Retrospective statistical analysis of 32 DTC patients with lung metastases after surgery received 131 I treatment in our hospital in the past decade. Before and after 131 I treatment, to observed the changes of whole body scan with I cervical and thoracic CT and serum thyroslobulin. Meantime to analyzed the chanses of peripheral blood liver and kidney function. Results The total effective rate of 131 I treatment DTC with lung metastasea reached to 84.4%. Also, different kind of blood cell, hemoglobin in peripheral blood, liver and kidney function were not affected by this method. Conclusion Application of 131 I treatment of DTC with lung metastases was a good means with significant clinical effect and few adverse reactions.