度洛西汀合并菩提树放松技术对焦虑障碍疗效及心率变异性的影响

摘要

目的：探讨菩提树放松技术合并度洛西汀对焦虑障碍心率变异性（HRV）的影响。方法将124例焦虑障碍患者随机分为研究组（度洛西汀合并菩提树放松治疗）和对照组（单用度洛西汀）各62例，采用 Zung 氏焦虑自评量表（SAS）和汉密尔顿焦虑量表（HAMA）于治疗前及治疗后第2、4、6、8周末进行评定，并分别在每次干预前后监测 HRV 值。结果（1）治疗后第2、4、6、8周末两组 SAS 和 HAMA 评分均下降（P ＜0．05），研究组评分低于对照组（P ＜0．01）；治疗后第13、14、15、16次低频功率（LF）研究组低于对照组（P ＜0．05），高频功率（HF）研究组高于对照组（P ＜0．05）。（2）研究组焦虑严重指数与 LF ／HF 值呈正相关（P ＜0．05）。结论度洛西汀合并菩提树放松技术可以有效提高焦虑障碍患者的心率变异性和疗效。%Objective To investigate the influence of duloxetine combined with Bodhi tree relaxation technique on heart rate variability (HRV)in patients with anxiety disorder.Methods 124 patients with anxiety disorder were randomized into study group (62 cases)treated with duloxetine combined with Bodhi tree relaxation technique and control group (62 cases)treated with duloxetine monotherapy.All patients were assessed with Zung′s Self-Rating Anxiety Scale (SAS)and Hamilton Anxiety Scale (HAMA)at baseline and at the end of the 2nd ,4th ,6 th ,8th week of the treatment.HRV was measured before each relaxation and was re-measured after each relaxation.Results (1 )Scores of SAS and HAMA in both groups decreased significantly at the end of the 2nd ,4th ,6 th ,8th week when compared with the baseline (P <0.05).Scores of SAS and HAMA in study group were significantly lower than those in control group at each interview-point (P <0.01).Low frequency power (LF) at the 13 th ,14th ,15 th ,16 th measurement in study group were significantly lower than those in control group (P <0.05).High frequency power (HF)at these measure -point in study group were significantly higher than those in control group (P <0.05). (2)The anxiety severity index in study group was significantly positively correlated with the score of LF /HF (P <0.05 ). Conclusion Duloxetine combined with Bodhi Tree relaxation technique is effective in improving the heart rate variability and curative effect in patients with anxiety disorder.