目的：观察狗牙髓直接封蟾毒和砷剂后其超微结构的改变。方法：3只狗36个牙暴露牙髓后直接覆盖蟾毒或砷剂，在1、2、6、24 h后处死狗。将狗牙髓制成厚约0．1μm超薄切片，于透射电镜(JEM－2000EX)下观察。结果：封药1 h，蟾毒组变化较砷剂组明显；封药2 h，蟾毒组神经损伤加重，而砷剂组毛细血管扩张明显；封药6 h，砷剂组变化较蟾毒组明显；封药24 h，蟾毒组变化与砷剂组基本相似。结论：蟾毒与砷剂两者对牙髓的毒性作用均包括血管毒、神经毒和原生质毒三种作用，其中，砷剂的血管毒性较强，而蟾毒的神经毒与原生质毒性较强。%Objective:To observe the effects of toadpoison and arsenic on the ultrastructure of dental pulp,Methods :Dental pulp of 36 teeth in 3 dogs was exposed by operation and then direct dressing with toadpoison paste or arsenic paste was performed. 1,2,6 and 24 hours after operation ,the pulps were processed and examined under a trasmission electron microscope (JEM-2000EX). Results:In toadpoison treated group ,the deformity of the basernembrane of pulp nerve ,swelling of metochondrion,degeneration of nerve axite were observed 1 h after dressing,and were more obvious in 2, 6 and 24 h. Damage of capillary and pulp cells were alsoobserved. In arsenic treated group ,swelling and break of capillaries ,deformity and degeneration of mitochondrion and endoplasmic reticulum in endoepithelial cells were observed,and were more obvious following time lasting. Damages of pulp nerve and pulp cells were also observed. Conclusion:Toadpoison and arsenic are toxic to pulp tissues. But the angiotoxicity of arsenic is stronger than that of toadpoison,the neurotoxicity and protoplasmic toxicity of toadpoison are stronger than those of arsenic.
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