珊瑚人工骨的生物学评价

摘要

目的：评价海南珊瑚人工骨的生物相容性。方法：参考上海市非直接接触血液的医用生物材料生物性能测试标准评价珊瑚人工骨的组织相容性进行了一系列体内及体外试验，包括：细胞毒性试验，溶血试验，急性全身毒性试验，热原试验，皮下种植，肌肉种植及骨内种植试验。结果：各实验结果均符合种植材料要求。结论：珊瑚人工骨具有良好的生物相容性，安全无毒，无溶血性，对组织刺激小，不含热原。%Objective:To evaluate the biological compatibility of coral as a bone transplant substitute.Methods:Coral collected from Hainan of China was tested with,a series of experiments for the study of cytotoxicity,hemolysis,general acute toxicity,pyrogen and bone inductivity of the materia.Results:The coral showed no cytotoxicity,hemolysis and pyrogen,while it induced new bone formation in bone defects.Conclusion:Coral has good biocompatibility in vitro and in vivo.