Objective:To study the influence of mesially impacted third molar on MMP8 and TIMP1 expression in gingival crevicular fluid ( GCF) of adjacent second molar. Methods: 64 soldiers were divided into four groups ( n = 16). In group A, the soldiers had second molars with normal- looking gingival flap overlying a mesially impacted mandibular third molar without history of pericoronitis. In group B, the soldiers had the same second and third mandibular molars as in group A but experienced pericoronitis of the third molar within six months. In group C the soldiers showed signs and symptoms of pericoronitis of the mandibular third molar. In group D the soldiers did not have the third molar and the mandibular second molars served as controls. GCF of second molars was collected, MMP8 and TIMP1 were measured. Sulcus bleeding index (SBI) , probing depth (PD) and plaque index (PI) of the related second molars were examined. Results: MMP-8 and TIMP1 concentrations in the gingival crevicular fluid in the four groups were different(C > B > A > D. A vs B, P > 0. 05 ; A vs C or D, B vs C or D and C vs D, P < 0. 05 ) . In clinical indexes, PI of group C was higher than that of group D (P < 0. 05) , and PD in group A, B and C was deeper than in group D (P < 0.05). Conclusion: The mesially impacted third molars may stimulate the MMP8,TIMP1, MMP8/TIMP1 expression and increase PD of the adjacent second molar, and they might be potential risk factors of periodontal inflammation of the second molar. Pericoronitis of the third molar might increased the effects.%目的:探讨第三磨牙近中阻生对邻近磨牙龈沟液中MMP8和TIMP1的影响.方法:选择64例口腔科就诊的战士,分为4组,A组下颌第二磨牙伴第三磨牙近中阻生,第三磨牙无冠周炎病史,龈瓣颜色正常；B组下颌第二磨牙伴第三磨牙近中阻生,6个月内第三磨牙有冠周炎病史,龈瓣颜色正常；C组下颌第二磨牙伴第三磨牙近中阻生,有冠周炎；D组无下颌第三磨牙,第二磨牙作为对照.收集下颌第二磨牙龈沟液,检测MMP8和TIMP1水平,同时测定第二磨牙龈沟出血指数、探诊深度和菌斑指数等指标.结果:MMP8和TIMP1各组间均有统计学差异(C组＞B组＞A组＞D组).MMP8/TIMP1 B组和A组之间无明显差别,其余各组间差异有统计学意义.临床指标中,C组的菌斑指数明显高于D组,A、B、C组的探诊深度大于D组.结论:第三磨牙近中阻生在无炎症状态时可引起第二磨牙龈沟液MMP8、TIMP1、MMPS/TIMP1和探诊深度等牙周炎潜在致病 因素的变化,出现冠周炎症时变化更加显著.
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